PhD Research Fellow in cell biology–proteostasis network control of multiprotein complexes lifecycle

PhD Research Fellow in cell biology–proteostasis network control of multiprotein complexes lifecycle
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PhD Research Fellow in cell biology – proteostasis network control of multiprotein complexes lifecycle.

There is a vacancy for a PhD Research Fellow in cell biology - proteostasis network control of multiprotein complexes lifecycle at the Department of Biological Sciences . The position is for a fixed-term period of 3 years with the possibility of a 4 th year with compulsory other work (e.g. teaching duties at the Department). The position will be funded by The University of Bergen.

About the project/work tasks:

• The research group uses genetics, biochemistry and mass spectrometry proteomics techniques to investigate principles of proteostasis control. Specific research focus of the group is understanding the lifecycle of large multiprotein complexes (see Onischenko et al, Cell, 2017 and 2020). The PhD project is aimed at characterizing assembly and turnover of one of such complexes - mitochondrial oxidative phosphorylation system (OXPHOS) - under normal and perturbed proteostasis conditions observed in ageing-related disorders.
• The candidate will work on establishing biochemical analysis of assembly dynamics and turnover of OXPHOS complexes in budding yeast and in mammalian cells and examining the impact of experimentally induced proteostasis control defects. The project will take extensive use of molecular cloning, biochemical isolation of protein complexes both in budding yeast and mammalian cells and computational analysis of large-scale experimental datasets. Large part of the experimental data will be acquired by mass spectrometry proteomics to quantitatively characterize the parameters of the OXPHOS lifecycle.
• The successful candidate will have the opportunity to contribute to development of the project in line with his/her interests.
• The fellow may also be involved in the supervision of students at the bachelor- and master levels.

Qualifications and personal qualities:

• Applicants must hold a master's degree or equivalent education in molecular biology, biochemistry, chemistry or physics. Master students can apply provided they complete their final master exam before 01.07.2024. It is a condition of employment that the master's degree has been awarded.
• Experience from molecular cloning techniques and protein biochemistry techniques such as protein affinity purification is a requirement.
• Ability to computationally analyse omics datasets in R, Python or alike is a great advantage.
• Familiarity with budding yeast and/or mammalian cell culture models is an advantage.
• Experience from mass-spectrometry proteomics is an advantage.
• Applicants must be able to work independently and in a structured manner and demonstrate good collaborative skills.
• Applicants must be proficient in both written and oral English.

Personal and relational qualities will be emphasized. Ambitions and potential will also count when evaluating the candidates.

Special requirements for the position

The University of Bergen is subjected to the regulation for export control system. The regulation will be applied in the processing of the applications

About the PhD position (applies to university PhD positions):

The fellowship will be for a period of 3 years, with the possibility for a 4th year, consisting of 25 % compulsory work (e.g. teaching responsibilities at the department) distributed over the employment period. The 4th year is contingent on the qualifications of the candidate and the teaching needs of the department and will be decided by the head of department upon appointment. The employment period may be reduced if you have previously been employed in a qualifying position (e.g. research fellow, research assistant).

About the research training

As a PhD candidate, you must participate in an approved educational programme for a PhD degree within a period of 3 years. The deadline for applying for admission to the PhD programme at The Faculty of Mathematics and Natural Sciences is 2 months after you start your position or after the start of the research project that will lead to the PhD degree. It is a condition that you satisfy the enrolment requirements for the PhD programme at the University of Bergen.

We can offer:

• A good and professionally stimulating working environment.
• Salary as PhD research fellow (code 1017) in the state salary scale. This constitutes a gross annual salary of NOK 532 200 (equivalent to pay grade 54). Further increases in salary are made according to length of service in the position.
• Enrolment in the Norwegian Public Service Pension Fund
• Good welfare benefits

Your application must include:

• A brief account of the applicant's research interests and motivation for applying for the position.
• The names and contact information for two referees. One of these should be the main advisor for the master's thesis or equivalent thesis.
• CV
• Transcripts and diplomas showing completion of the bachelor's and master's degrees. If you have not yet completed your master's degree, please submit a statement from your institution confirming that the master's thesis has been submitted.
• Relevant certificates/references.
• Approved documentation of proficiency in English (if required, cf. English language requirements for PhD admission ). 
• A list of any works of a scientific nature (publication list).
• Any publications in your name.

The application and appendices with certified translations into English or a Scandinavian language must be uploaded at Jobbnorge.

General information:

For further details about the position, please contact Associate Professor Evgeny Onishchenko , Department of Biological Sciences, UiB, e-mail: [email protected].

For HR related questions please contact Adviser Therese Myhre Odfjell, [email protected]

The state labour force shall reflect the diversity of Norwegian society to the greatest extent possible. Age and gender balance among employees is therefore a goal. It is also a goal to recruit people with immigrant backgrounds. People with immigrant backgrounds and people with disabilities are encouraged to apply for the position

 

  

The University of Bergen applies the principle of public access to information when recruiting staff for academic positions.

Information about applicants may be made public even if the applicant has asked not to be named on the list of persons who have applied. The applicant must be notified if the request to be omitted is not met.

The successful applicant must comply with the guidelines that apply to the position at all times.

For further information about the recruitment process, click here .

Life as a PhD candidate at UiB

Marion Claireaux tells about life and work as a PhD candidate at UiB.

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About UiB

The University of Bergen is a renowned educational and research institution, organised into seven faculties and approximately 54 institutes and academic centres. Campus is located in the centre of Bergen with university areas at Nygårdshøyden, Haukeland, Marineholmen, Møllendalsveien and Årstad. 

There are seven departments and several centres at Faculty of Mathematics and Natural Sciences. Read more about the faculty  and departments.  

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Deadline

1st April 2024

Employer

University of Bergen

Municipality

Bergen

Scope

Fulltime (1 positions) Fulltime (%)

Duration

Fixed Term

Place of service
Thormøhlens gate 53 A, 5006 Bergen

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