Post-doctoral position in microfluidic cell sorting and process automation

Institute of Photonic Sciences, Luxembourg

Updated: about 6 hours ago
Deadline: ;

The successful candidate will be joining the Neurophotonics and Mechanical Systems Biology group led by Prof. Dr. Michael Krieg in the framework of an international collaboration between ICFO, LMU Munich and UC Santa Barbara. The main task of the advertised position is to build multilayer optofluidic device for single cell sorting followed by DNA extraction and on chip amplification. The device shall combine optical sorting of cells expressing fluorescent biomarkers for on chip lifespan determination and DNA extraction. The ultimate goal is to decipher the role of replicative lifespan of yeast cells in mitochondrial health and DNA damage.

The Krieg lab has extensive experience in mechanobiology in C. elegans and zebrafish using advanced microscopy techniques, microfluidics and optical tweezers to interrogate fundamental mechanical processes in neurons and during development. We primarily use C. elegans due to its many advantages as a genetic model system and its wealth of mutant and cell biological tools. Also, we combine experiments with theory and simulations to obtain a systems view of cellular processes.

The advertised position is targeted at Postdocs with prior experience in advanced microfluidics for bio-applications/bioengineering with strong background in molecular biology and microscopy. The project is highly interdisciplinary and collaborative and the successful applicant is expected to work in a team of engineers, physicists and biologists to build an automated devices for tracking healthspan of individual cells across multiple generations. It builds on previous observation ind technologies developed in the Krieg and Osman labs and further information can be found here:

https://www.science.org/doi/10.1126/sciadv.abi8886
https://doi.org/10.1101/2022.07.08.499356
http://livinglight.icfo.eu/?page_id=632

The project is funded by a recently awarded HFSP Research grant between the Osman, Krieg and Shraiman labs and the candidate has the opportunity to travel internationally to the participating labs in Munich (Osman lab) and Santa Barbara (Shraiman lab).

Support of the "Human Frontier Science Program".


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