8 Feb 2024
Job Information
- Organisation/Company
Luxembourg Institute of Health- Department
Ressources Humaines- Research Field
Biological sciences » Other- Researcher Profile
Recognised Researcher (R2)- Country
Luxembourg- Application Deadline
30 Apr 2024 - 12:00 (Europe/Luxembourg)- Type of Contract
Temporary- Job Status
Full-time- Hours Per Week
40- Offer Starting Date
1 Jul 2024- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
Funded as a FNR-FWF WEAVE project, Dr. Annette Kuehn, Research Group “Molecular and Translational Allergology” at the Department of Infection and Immunity is seeking a Postdoctoral Fellow in Immunosciences.
PROJECT
Food allergy is a major public health issue worldwide. Patients present with variable clinical profiles, disease progression and severity, which is part of the unpredictable nature of food allergy. There is a clear need to dissect the immune mechanisms underlying clinical food allergy. This will allow stratifying patients into mechanism-based endotypes considered vital for improving patient care and reducing the allergy burden. This project aims to advance the fundamental knowledge of food allergies. Novel approaches are needed for better understanding of the in-vivo cascade of allergic events, covering adaptive and innate immune responses, in order to identify clinically relevant key elements that correlate with clinical outcome in diagnosis and treatment. Therefore, the present project will address the in-vivo immune response in acute episodes of food allergy. We will focus on analyses of blood samples taken during oral food challenges with peanut and cashew nut, both main elicitors of food-induced anaphylaxis, to study functional immune changes in a longitudinal mode. Integrating those clinical and immune data will generate computational models to endotype patients and to decipher the allergic cascade of clinical food allergy. This project is built on a transdisciplinary consortium of food allergy experts from clinics, immune research and data science. This postdoctoral researcher position will be in a highly recognized and internationally visible research team, at the Department of Infection and Immunity (research group Dr. Annette Kuehn), LIH. The FNR-FWF WEAVE funded project will be in close collaboration with Dr Thomas Eiwegger, Research Group “Clinical Immunology” at the Karl-Landsteiner University, Austria.
KEY ACCOUNTABILITIES
- Plan, direct, and conduct specialized research experiments to understand immunological mechanism in the context of type2 immune responses
- Develop and coordinate flow cytometry experiments (research group A. Kuehn) in the context of a clinical study with the linked bioinformatics analysis
- Collaborate with international partners to achieve research goals
- Prepare manuscripts for publication in peer-reviewed journals
- Present research findings at national and international conferences
- Train and co-supervise under- and post-graduate students and technicians
KEY SKILLS, DEMONSTRATED EXPERIENCE AND QUALIFICATIONS
We are looking for a highly motivated, perseverant, organized, and flexible postdoctoral fellow, willing to work in a competitive, interdisciplinary, cooperative and international research project.
- Ph.D. in Cell Biology, Immunology, or related field
- Experience with in vivo, ex vivo or in vitro human models
- Strong background and publication record in allergic disease and/or human immunology
- Hands-on experience in cytometry and sorting experience
- Good to have: experience with analyzing multidimensional immune data
- Strong written and oral communication skills in English
For any further information please visit: Dr. Annette Kuehn (PI of the project): https://orcid.org/0000-0003-0474-2135
In Short...
- Contract duration : 36 months
- Location : rue Henri Koch 29 - 4354 Esch-sur-Alzette
- Start date : ASAP
- Ref : MC/PDFI0124/AK/DII
How to apply
Applications including a letter detailing your motivation and a curriculum vitae should be sent through our website via the apply button below.
Please apply ONLINE formally through this web page.
Applications by email will not be considered.
All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.
Requirements
- Research Field
- Biological sciences » Other
- Education Level
- PhD or equivalent
Skills/Qualifications
Funded as a FNR-FWF WEAVE project, Dr. Annette Kuehn, Research Group “Molecular and Translational Allergology” at the Department of Infection and Immunity is seeking a Postdoctoral Fellow in Immunosciences.
PROJECT
Food allergy is a major public health issue worldwide. Patients present with variable clinical profiles, disease progression and severity, which is part of the unpredictable nature of food allergy. There is a clear need to dissect the immune mechanisms underlying clinical food allergy. This will allow stratifying patients into mechanism-based endotypes considered vital for improving patient care and reducing the allergy burden. This project aims to advance the fundamental knowledge of food allergies. Novel approaches are needed for better understanding of the in-vivo cascade of allergic events, covering adaptive and innate immune responses, in order to identify clinically relevant key elements that correlate with clinical outcome in diagnosis and treatment. Therefore, the present project will address the in-vivo immune response in acute episodes of food allergy. We will focus on analyses of blood samples taken during oral food challenges with peanut and cashew nut, both main elicitors of food-induced anaphylaxis, to study functional immune changes in a longitudinal mode. Integrating those clinical and immune data will generate computational models to endotype patients and to decipher the allergic cascade of clinical food allergy. This project is built on a transdisciplinary consortium of food allergy experts from clinics, immune research and data science. This postdoctoral researcher position will be in a highly recognized and internationally visible research team, at the Department of Infection and Immunity (research group Dr. Annette Kuehn), LIH. The FNR-FWF WEAVE funded project will be in close collaboration with Dr Thomas Eiwegger, Research Group “Clinical Immunology” at the Karl-Landsteiner University, Austria.
KEY ACCOUNTABILITIES
- Plan, direct, and conduct specialized research experiments to understand immunological mechanism in the context of type2 immune responses
- Develop and coordinate flow cytometry experiments (research group A. Kuehn) in the context of a clinical study with the linked bioinformatics analysis
- Collaborate with international partners to achieve research goals
- Prepare manuscripts for publication in peer-reviewed journals
- Present research findings at national and international conferences
- Train and co-supervise under- and post-graduate students and technicians
Specific Requirements
KEY SKILLS, DEMONSTRATED EXPERIENCE AND QUALIFICATIONS
We are looking for a highly motivated, perseverant, organized, and flexible postdoctoral fellow, willing to work in a competitive, interdisciplinary, cooperative and international research project.
- Ph.D. in Cell Biology, Immunology, or related field
- Experience with in vivo, ex vivo or in vitro human models
- Strong background and publication record in allergic disease and/or human immunology
- Hands-on experience in cytometry and sorting experience
- Good to have: experience with analyzing multidimensional immune data
- Strong written and oral communication skills in English
For any further information please visit: Dr. Annette Kuehn (PI of the project): https://orcid.org/0000-0003-0474-2135
- Languages
- ENGLISH
- Level
- Excellent
Additional Information
Benefits
In Short...
- Contract duration : 36 months
- Location : rue Henri Koch 29 - 4354 Esch-sur-Alzette
- Start date : ASAP
- Ref : MC/PDFI0124/AK/DII
How to apply
Applications including a letter detailing your motivation and a curriculum vitae should be sent through our website via the apply button below.
Please apply ONLINE formally through this web page.
Applications by email will not be considered.
All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- Luxembourg Institute of Health
- Country
- Luxembourg
- Geofield
Where to apply
- Website
https://www.lih.lu/en/job/?value=MC/PDFI0124/AK/DII
Contact
- State/Province
Strassen- City
Strassen- Website
http://www.lih.lu- Street
1A-B, rue Thomas EdisonL-1445 StrassenLuxembourg- Postal Code
1445
STATUS: EXPIRED
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