The central histaminergic system is an important modulator of memory related to adverse events and the integrity of the brain histamine system is necessary for the consolidation of this type of memory.
In this context, it is essential to understand the spatio-temporal frames allowing the central histaminergic system to organize behavioural responses associated with adverse events. For this purpose, the candidate will explore the neuronal circuits that are activated in response to an aversive stimulus, investigating the role of the neuronal histaminergic system in this activation.
Moreover, he/she should produce an anatomic map of the histaminergic connections involved in memory. In particular, the candidate should optimize a method able to reconstruct a macroscopic volume with microscopic resolution using the light-sheet microscopy (LSM) techniques coupled with chemical tissue clearing to quantify and analyze all activated histaminergic neurons.
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