Iron oxide magnetic nanoflowers as potential theranostics: Assessing the relationship between their structure-properties and their function in vivo

19 Mar 2024
Job Information

Organisation/Company

Sorbonne University

Department

Chemistry Department

Research Field

Biological sciences » Laboratory animal science
Medical sciences » Cancer research
Chemistry » Biochemistry

Researcher Profile

First Stage Researcher (R1)

Country

France

Application Deadline

7 Apr 2024 - 12:00 (Europe/Paris)

Type of Contract

Temporary

Job Status

Full-time

Hours Per Week

35

Offer Starting Date

1 Jun 2024

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

The field of nanomedicine is receiving increasing attention and has enormous potential for a plethora of pathological conditions, including cancer. One of the main advantages of nanomaterials is the ability to combine multiple modalities in one platform, allowing the nanomaterials to be used simultaneously for diagnostic and therapeutic applications and to use multiple therapeutic options simultaneously. Among these nanoparticles are iron oxide magnetic nanoflowers whose structure-property-function relationship is investigated in PHENIX lab showing exciting functions in heat generation (magnetic hyperthermia, photothermia) as well as in MRI and MPI imaging. However, the main bottlenecks hindering the full use of nanomaterials for biomedical purposes is the need for a higher level of selectivity in terms of targeted delivery of the nanomaterials to the target cells, along with the development of new, alternative therapeutic options. In this postdoc and in the frame of a collaboration between Inorganic Colloids group in PHENIX (Sorbonne University, France) and NanoHealth and Optical Imaging Group (KU Leuven, Belgium) we propose to investigate these topics which are central in a multidisciplinary way by making extensive use of non-invasive imaging (optical imaging and magnetic particle imaging) to investigate the biodistribution and functionality of the nanoformulations.

Requirements

Research Field

Biological sciences » Laboratory animal science

Education Level

PhD or equivalent

Research Field

Medical sciences » Cancer research

Education Level

PhD or equivalent

Research Field

Chemistry » Biochemistry

Education Level

PhD or equivalent

Skills/Qualifications

Candidate profile: The applicant holds a PhD in the fields of biology, medical sciences, pharmaceutical sciences, biochemistry, bioengineering, or similar and has: i) Experience in handling and testing mice and performing related biochemical tests, ii) Experience working with in vivo optical imaging. iii) Experience with histology and all related skills, iii) Experience with fluorescence microscopy is desirable but not a must, iii) Experience with MPI is desirable but not a must, iv) Ideally, the applicant has a Felasa B animal handling certificate.  Applicant must be able to communicate well in English. 

Main responsibilities:  i) Applicant must have sound knowledge and experience in performing cell culture techniques and basic in vitro assays, ii) Must be able to perform non-invasive imaging tasks, example; optical imaging, FLECT-CT and MPI. The latter two are desirable but not a must, iii) The applicant will work with different mouse tumor models. This work includes intravenous and subcutaneous injections, dissection of the mice, and processing of different organs.

Languages

ENGLISH

Level

Excellent

Research Field

Biological sciences » Laboratory animal scienceMedical sciences » Cancer researchChemistry » Biochemistry

Years of Research Experience

1 - 4

Additional Information
Benefits

Monthly salary is 2 889,51 €  (monthly gross)

Selection process

Interested and highly motivated candidates should apply by submitting to

:     [email protected] r ; [email protected]

a cover letter stating why they are interested in this position, a full CV with a list of publications, and two academic references (with address, phone number and email). 

Work Location(s)

Number of offers available

1

Company/Institute

NanoHealth and Optical Imaging Group at KU Leuven in Belgium

Country

Belgium

City

Leuven

Geofield

Where to apply

E-mail

[email protected]

Contact

City

PARIS

Website

https://phenix.cnrs.fr/

Street

case 51 4 place Jussieu 75005 PARIS

Postal Code

75005

E-Mail

[email protected]
[email protected]

STATUS: EXPIRED