Specialist for Cellular Glycoengineering and Inducible Gene Editing - DTU Bioengineering

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Specialist for Cellular Glycoengineering and Inducible Gene Editing - DTU Bioengineering
Kgs. Lyngby, Denmark

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Job Description

Expert support person for cellular Glycoengineering and inducible gene editing systems of iPSC-NK.

A 3-year position is available within the research group ‘Biotherapeutic Glycoengineering and Immunology’ headed by Professor Steffen Goletz and is funded by the DigitSTEM initiative. Our research group belongs to the Section of Protein Science and Biotherapeutics at the Department of Biotechnology and Biomedicine at DTU. The position will be available from April 2024. 

In our research group, we apply and develop advanced next generation antibody engineering as well as cellular and molecular glycoengineering technologies to elucidate the role of glycosylations within complex immunological networks and disease and to generate novel therapeutic strategies and drug candidates. Our main therapeutic interest is within immunooncology as well as infectious gastrointestinal and lung diseases. One focus lies within cellular glycoengineering of human innate immune cells for highly effective cell-based immunotherapeutics and the design and development of their manufacturing processes. We also have a strong focus on innovation and entrepreneurship.

The DigitSTEM initiative is a four-year stem cell focused research collaboration between The Technical University of Denmark (DTU), the The Novo Nordisk Foundation Center for Stem Cell Medicine (renew) at University of Copenhagen, and Bioneer A/S that aims at developing new in vitro disease models and therapeutics using human pluripotent stem cells (hPSCs). The current position focuses on cellular glycoengineering and generation of inducible gene editing systems within our of differentiation of human induced-pluripotent stem cells (iPSCs) into effective NK-cells.

Our expectations of you
You will work with a team of Senior scientists, postdocs, and PhD students and in close collaboration with academic and industrial collaborators within the DigitSTEM initiative to establish a novel iPSC-derived NK-cell platform for next generation biotherapeutics. 

You are highly motivated and must have solid laboratory experiences in cellular glycoengineering, glycobiology, human cell engineering, gene editing including knock-out and knock-in technologies, inducible gene editing systems, and stem cell engineering and differentiation. 

Prior work in this field is required. 

Deep knowledge and skills in genetic engineering of human iPSC, cell-line development, iPSC generation,  glycobiology, glycoengineering, glycoanalytics. Knowledge in proteomics will be of advantage. The successful applicant should hold a PhD in a relevant life-science discipline (stem cell biology, immunology or alike), have excellent communication skills and be extensively trained in stem cell biology, gene editing, glycobiology, cell culture systems, and computational data analysis.

What we offer in return
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

Salary and appointment terms
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. 

The period of employment of the full-time position is 3 years. 

Starting date is as soon as possible.

Application and contact
Please submit your online application no later than 16 February 2024  Open the “Apply now” link, fill out the form and attach your motivated application, CV and exam certificates. 

Additional information may be obtained from Prof. Dr. Steffen Goletz, [email protected]

You can read more about the department at www.bioengineering.dtu.dk

If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark . Furthermore, you have the option of joining our monthly free seminar

Applications received after the deadline will not be considered.

All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.

The Department of Biotechnology and Biomedicine (DTU Bioengineering) is an international leader in the areas of biotechnology and biomedicine. Our engineering approach to all aspects of biotechnology and biomedicine positions us as a valuable player with unique competences in a growing bio-based economy and with health systems transforming towards personalized medicine. We have a clear focus on the needs in the life science industry and point towards innovation, new businesses, and scientific services for the benefit of society. The department has extensive collaborations with national and international research units and industry. DTU Bioengineering has approx. 400 employees, of which 2/3 are scientific staff. The department is located at DTU Lyngby Campus.

Technology for people
DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear mission to develop and create value using science and engineering to benefit society. That mission lives on today. DTU has 13,500 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. DTU has campuses in all parts of Denmark and in Greenland, and we collaborate with the best universities around the world.

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Job Info

• Job Identification 3107
• Job Category TAP
• Posting Date 02/02/2024, 03:21 AM
• Apply Before 02/16/2024, 05:59 PM
• Locations Søltofts Plads, Kgs. Lyngby, 2800, DK

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