Research Assistant in mammalian cell and bioprocess engineering - DTU Biosustain

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Research Assistant in mammalian cell and bioprocess engineering - DTU Biosustain
Kgs. Lyngby, Denmark
Job Description

The Novo Nordisk Foundation for Biosustainability (DTU Biosustain) at the Technical University of Denmark is seeking a highly motivated research assistant a with an interest in cell line engineering and bioprocess development. If your areas of interest and competence are molecular biology, cell line design and engineering and you are looking to gain experience in bioprocess development and metabolic modelling, while working on projects that will make an impact on the world, this is your chance. Your personal efforts will enable and accelerate works towards the development of new mammalian cell-based platforms for the biomanufacturing of pharmaceuticals like recombinant adeno-associated viruses (rAAVs). You will work on cell line generation for two main goals. The first one will be to improve the production of rAAVs and the second will be to generate model cell lines for metabolic modelling. Through this, you will get the opportunity to utilize everything you know and help break new ground at the very forefront of what is possible. 

Skill acquisition opportunities
At a more personal level, you will get the opportunity to learn state-of-the-art genetic engineering technology and methods related to synthetic biotechnology. You will also have the opportunity to learn how to develop a bioprocess using new mammalian platforms and how to integrate metabolic modelling. You must be open to learning new information within the biology and engineering domains, as well as be open to contributing with your expertise and ideas at our regular group meetings. You will be building the foundation for world-class scientific results.

The projects and tasks
Your mission is to develop new mammalian cell lines for the biomanufacturing of recombinant adeno-associated viruses (rAAVs) and for metabolic modelling. You will:

• Use cell engineering tools to develop the new mammalian cell-based platform (75% of the time).
• Generate knock outs and knock ins for relevant pathways in rAAV production.
• Generate knock outs and knock ins for relevant pathways in central carbon metabolism and the surrounding regulatory network.
• Optimize its performance via bioprocess engineering methods (e.g. running the ambr® system, 25% of the time)

Competencies of the ideal candidate
As a formal qualification, you must have a two-year master's degree (120 ECTS points) or a similar degree with an academic level equivalent to a two-year master's degree.

We also ask that you are motivated by working in an international environment with colleagues and partners from all over the world. Added to this, the CV of the ideal candidate comprises: 

• Experience with mammalian cell cultures.
• Experience with standard molecular biology techniques (e.g. cloning, plasmid generation…etc).
• Experience with CRISPR/Cas technology.
• Motivation for learning new techniques.
• Optional: experience in operating the ambr® system.
• Optional: familiarity with coding (python, R).
• Motivation to work with the ambr® system.
• A degree in biotechnology/biochemistry or related.
• Ability to work independently and as part of a team. 
• Ability to successfully work on multiple concurrent projects and meet deadlines.

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility. 

Salary and terms of employment 
The appointment will be based on the collective agreement with the Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. 

The period of employment is 2 years. 

You can read more about career paths at DTU here .

Further information 
Further information may be obtained from Jesús Lavado García at [email protected]  or Nicholas Luke Cowie at [email protected]

You can read more about DTU Biosustain at www.biosustain.dtu.dk  

If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark .

Application procedure 
Your complete online application must be submitted no later than 15  March 2024 (23:59 Danish time). 

Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply now", fill out the online application form, and attach all your materials in English in one PDF file. The file must include:

• Application (cover letter)
• CV
• Academic Diplomas (MSc)

Applications received after the deadline will not be considered.

All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply.

The Novo Nordisk Foundation Center for Biosustainability (DTU Biosustain)
Recent progress in our ability to read and write genomic code, combined with advances in automation, analytics and data science, has fundamentally changed the scope and ambition of harnessing the potential of biological systems. Big data approaches and analysis of biological systems are key research instruments at the Center. DTU Biosustain utilizes these advances for microbial cell factory design to foster sustainable lifestyles in relation to three application areas: Sustainable Chemicals, Natural Products, and Microbial Foods. 

Technology for people
DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear mission to develop and create value using science and engineering to benefit society. That mission lives on today. DTU has 13,500 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. DTU has campuses in all parts of Denmark and in Greenland, and we collaborate with the best universities around the world.

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Job Info

• Job Identification 3224
• Job Category VIP B
• Posting Date 02/22/2024, 03:42 AM
• Apply Before 03/15/2024, 06:59 PM
• Locations Søltofts Plads - via Henrik Dams Alle, Kgs. Lyngby, 2800, DK

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