Postdoctoral Position in Neuroproteomics

A two-year postdoctoral position is available in our Neurobiology project DEVELOPNOID, aiming at characterizing neurological diseases using stem-cell derived brain organoids and Omics technologies.

Background:
Recently, the possibility to differentiate human induced pluripotent stem cells (iPSCs) into organized 3D structures, brain organoids, has provided an efficient tool to study neuronal development using more mature neurons than neurons obtained from 2D culture systems. Brain organoids are formed by cellular self-organization of neurons and astrocytes, resulting in the formation of distinct and interdependent brain regions ex vivo.

Moreover, brain organoids developed over extended periods exhibit active neuronal networks, including the formation of organized and active synapses. The cellular diversity and 3D organization observed in brain organoids represent an advantage for modelling complex interactions observed in the neural microenvironment, including synaptic transmission in synaptosomes. Brain organoids are therefore ideal to study various neurological diseases using iPSCs generated from healthy and diseased patients and reveal disease pathogeneses distinct from any other model systems available.

The project aims at characterizing molecular processes underlying disease development in developing brain organoids derived from patient iPSCs using quantitative proteomics, modification specific proteomics (PTMomics), metabolomics, bioinformatics and imaging.

Qualifications
A successful candidate would have a PhD degree in biochemistry, cell biology, molecular biology, proteomics, or a related field and is highly motivated and innovative. A candidate should have significant experience in stem cell differentiation, generation of 3D cultures (brain organoids), functional proteomics, post-translational modification analysis or LC-based mass spectrometry. Excellent communication and writing skills and an ability to interact socially and scientifically with other laboratory members and collaborators are essential. Previous postdoc experience and a strong publication record are also strong merits.

Deadline: 2 February 2023.

Please see the full call, including how to apply, on www.sdu.dk .