Postdoc

About us

The Danish Cancer Society Research Center (DCRC) is an international research institute with 22 research groups and around 200 researchers and students from more than 20 nations.

The Nucleolar Stress and Disease group also has an international profile and includes researchers from postdocs to undergraduate students, a technician and the group leader Dr. Dorthe Helena Larsen. We work closely together in a friendly environment with high ambitions, and the recruited researcher will be supervised by Dr. Dorthe Helena Larsen. The group is an integrated part of the DCRC and actively participates in the scientific seminar series, invites speakers to the institute and takes part in social gatherings. Please visit our website  in order to read more about our group.

About the research project

Our research focuses on understanding the molecular pathways involved in the cellular response to DNA damage with particular focus on the nucleoli and the specialized genomic domain that clusters in this organelle, the ribosomal RNA genes (rDNA). We investigate how ribosomal DNA damage occurs, how it is repaired, and how different types of lesions are important for the onset and progression of cancer. Furthermore, we investigate how DNA damage pathways can be exploited to improve therapeutic approaches.

Currently, we offer a research project that focuses on the role of the BLM helicase in repair of rDNA and how rDNA instability contributes to the pathology of Bloom syndrome (caused by mutations in the BLM helicase). Furthermore, the project will search for new and more gentle treatment options for Bloom Syndrome patients based on new insights into the mechanisms underlying Bloom Syndrome.

About you

We expect you to:

• hold a PhD degree in Life Sciences or a related topic
• have solid laboratory experience within molecular and cellular biology 
• have a proven ability to plan, execute and complete a research project 
• have very good written and spoken English communication skills 
• be a team player with good collaboration skills
• be self-motivated, ambitious, responsible and like to work independently  

Knowledge of DNA damage, nucleolar biology or drug screening is an advantage 

We offer

You will be part of an international, inspiring, and informal work environment in an internationally recognized research center, ranked at the top among the leading universities and research institutions worldwide. Our research facilities include modern laboratories with in-house access to state of the art equipment.

The postdoc position is for two years with the possibility of extension. The starting date is 1 February 2023 or upon agreement.

Your salary and pension will be according to the current agreements between the Danish Cancer Society and the relevant trade union. Working hours are 37 hours per week.

You will be working at Strandboulevarden 49 i København Ø. We have a health-conscious canteen, a fruit scheme, a sports and art association, and the working hours are of course smoke free.

Non-Danish and Danish applicants may be eligible for tax reductions, if you have not lived in Denmark in the previous 10 years. Please feel free to contact [email protected]  if you have any questions regarding relocating to Denmark.

Further information

For further information please contact Dr. Dorthe Helena Larsen: [email protected] or visit our webpage .

Application

We are only receiving applications via the online system.

The application should contain:

• A motivation letter 
• CV (including education, stay abroad, research experience, publications, language skills and other relevant information for the position, max 2 pages) 
• List of publications
• PhD certificate or statement from the supervisor if the thesis is not officially approved 
• Preferentially one or two reference letters, alternatively listed references 

Application deadline 27 November 2022.

One in three Danes will at some point in their life be affected by cancer. Two out of three will become relatives. With so many people involved, the Danish Cancer Society wishes to bring people together in a strong and active community against cancer, where you as an employee can be part in making an important difference. The Danish Cancer Society is a democratic organisation, where local associations and volunteers contribute to reaching our goals of fewer people getting cancer, more surviving cancer and everyone getting the best possible life with and after cancer