Post Doc position in skin inflammation in cutaneous T cell lymphoma

We are looking for a highly motivated and dynamic researcher who will join the skin inflammation and cancer group as post doc for a full-time position in three years to commence as soon as possible.  

The appointee is expected to conduct research into the role of skin inflammation and skin barrier deficiency and its impact on the pathogenesis and treatment of cutaneous T-cell malignancies.

Information on the Department can be found at: https://isim.ku.dk

Our research

Our vision is to stop the chronic inflammation and break the immune privilege (tolerance) of cancers. Our goal is to discover novel molecular disease targets, innovative therapies, and ways to modify the immune system to fight disease. Our mission is to unravel how disturbances in the immune defense lead to chronic inflammatory skin diseases and cancer.

We perform basic and translational research and have a close collaboration with clinicians at dermatology departments in Denmark, EU, and USA. We take an interdisciplinary approach to science and are collaborating with a large national and international network of researchers in areas such as immunology, microbiology, pharmacy, bioinformatics, cancer biology and veterinary and clinical medicine. We believe in teamwork and have an inclusive and supportive working environment in an international, open-minded atmosphere with a diversity of nationalities among group members and at the Department at large.

Your job

Our primary interests are skin inflammation and cutaneous T cell lymphoma (CTCL), which is characterized by the presence of malignant T cells in chronically inflamed skin. We focus on inflammatory skin responses, cytokine signaling, novel oncogenic pathways, cellular heterogeneity at the single cell level, crosstalk between malignant and non-malignant skin cells, and the role of bacterial products, metabolites, and toxins fueling chronic inflammation, malignant transformation and disease progression. Your tasks would be to conduct research into the role of skin inflammation and skin barrier deficiencies in cutaneous T-cell lymphoma and the implications for the pathogenesis and drug resistance in cutaneous T-cell malignancies. These tasks involve tissue culture of primary cells, single cell transcriptomics, special transcriptomics, high-level multi-parameter flow-cytometry and cell sorting, and analysis of large sets of data and well as functional studies in vitro and in vivo of malignant and non-malignant T cells and their interactions with stromal cells and keratinocytes.

The post docs’s responsibilities will primarily consist of:

• research, including publication/academic dissemination duties
• research-based teaching
• sharing knowledge with society

Profile

We are looking for a highly motivated and enthusiastic scientist with the following competencies and experience:

Essential experience and skills:

• You have a PhD in immunology
• You are highly experienced in working with human 2D and 3D skin models, skin barrier proteins, and tissue culture of primary human T cells
• You have experience from publishing as first author in recognized international, peer reviewed journals
• You have an active interest in cutaneous T cell lymphoma, inflammatory skin disorders, and epigenetic regulation of malignant or non-malignant T cells
• Proficient communication skills and ability to work in teams
• Excellent English skills written and spoken

Desirable experience and skills:

• Experience from working with ex vivo sorting of diverse human T cell subsets, and co-culture models
• You have experience working with single cell transcriptomics using the 10X platform, high-level multi-parameter flow-cytometry, and/or spacial transcriptomics using the GeoMx platform
• International research experience e.g. from being visiting scientist, research fellow, or as part of your PhD, or similar.
• Experience from teaching during your PhD carreer is an advantage

Place of employment

The place of employment is at the Department of Immunology and Microbiology, Panum Institute, University of Copenhagen. We offer creative and stimulating working conditions in a dynamic and international research environment. Our research facilities include modern laboratories and access to state-of-the-art core-facilities for flow cytometry, single cell sequencing, microscopy, animal facilities etc.

Terms of employment

The employment as Post Doc is a full time and fixed-term position for 3 years. Starting date is July 1st 2023 or after agreement.

Salary, pension and terms of employment will be in accordance with the agreement between the Ministry of Finance and AC (Danish Confederation of Professional Associations). Currently, the monthly salary starts at 32.944 DKK. Depending on qualifications, a supplement may be negotiated. The employer will pay an additional 17.1 % to your pension fund.

Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.

The position is covered by the “Memorandum on Job Structure for Academic Staff at the Universities” of June 28, 2013.

Questions
For further information, please contact Professor Niels Ødum, [email protected] .

Foreign applicants may find this link useful: https://www.ism.ku.dk/ (International Staff Mobility).

Application procedure
Your online application must be submitted in English by clicking ‘Apply now’ below. Furthermore your application must include the following documents/attachments – all in PDF format:

1. Motivated letter of application (max. one page)

2. CV incl. education, work/research experience, language skills and other skills relevant for the position

3. A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do

4. List of publications

5. Teaching portfolio if applicable

Application deadline: 15 April 2023, 23.59pm CET

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at https://employment.ku.dk/faculty/recruitment-process/

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation. Appointment will be based on merit alone.

Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.