Postdoctoral Fellow in Functional Genomics group

Central European Institute of Technology of Masaryk University (CEITEC MU) 

Brno, Czech Republic | www.ceitec.eu

We are the Czech Republic’s flagship basic research institute based at Masaryk University. Our modern in-house core facilities, which provide open access to the latest technologies and expertise, currently support more than 500 researchers from over 35 countries, who are together pushing the boundaries of knowledge in the areas of structural biology, molecular medicine, genomics and proteomics of plant systems, and neuroscience.

Our postdoctoral program  will enable you to participate in one of many exciting scientific projects addressing current global issues related to health and the quality of human life. You will have the opportunity to discuss and develop ideas and train your ability to reason in a scientific manner, formulate hypotheses independently, to innovate, and to perform independent research. It is an excellent opportunity to fully develop the skills acquired throughout your PhD studies. You will have access to a professional administration supporting you with grant preparation and administration, with technology transfer, science communication and with other areas of modern research management. You will have the chance to participate in a wide range of scientific and career development events and become a valued member of our vibrant multinational scientific community.

About this position 

A post-doctoral position is open in the lab of Dr. Michal Šmída (https://www.ceitec.eu/ceitec-mu/michal-smida-research-group/rg214 ) to participate in research focused on the identification of novel targets for therapy of leukemias, particularly acute myeloid leukemia (AML) and chronic lymphocytic leukemia (CLL). The research group is investigating molecular mechanisms essential for malignant cells and/or responsible for developing resistance to therapy and assesses how to exploit them for novel personalized therapy. We are seeking a talented person with expertise in cell biology, molecular biology and biochemistry to perform various drug and CRISPR/Cas9 cellular screens with following in-depth validation and detailed elucidation of molecular mechanisms. The research project will investigate the mechanisms of resistance that arise in CLL or AML patients to the modern targeted therapies. The aim will be to propose novel molecular targets to break the resistance and thereby enhance the success rate of the therapy. The project will include translational research using mouse models and primary patient material. State-of-the-art technologies such as genome-wide CRISPR/Cas9 screening, next-generation sequencing or single-cell sequencing are available in the laboratory and/or local core facilities and are accessible on a regular basis.

We are seeking a creative, independent, and driven individual with documented research experience related to this position. Candidates with strong research experience in cancer biology and personalized medicine are encouraged to apply.

Research will be conducted at CEITEC located on the life science campus of Masaryk University (Brno, Bohunice, https://www.ceitec.eu/ ).