Mechanisms of primary cilia formation

13 Jan 2024
Job Information

Organisation/Company

Masaryk University, Faculty of Medicine

Research Field

Medical sciences » Medicine

Researcher Profile

First Stage Researcher (R1)

Country

Czech Republic

Application Deadline

28 Feb 2024 - 23:00 (UTC)

Type of Contract

Not Applicable

Job Status

Other

Offer Starting Date

1 Sep 2024

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

Affiliation: Masaryk University, Faculty of Medicine
Study program: Ph.D. program Biomedical Sciences
Specialization: Biochemistry and Molecular Biology
Workplace: Department of Histology and Embryology
Mode: Full-time
Supervisor: Lukáš Čajánek, Ph.D.
Lab web: https://www.cajaneklab.com/
Funding: Czech Science Foundation
Title: Mechanisms of primary cilia formation

Brief annotation:
The primary cilium is an antenna-like organelle that has emerged as a fundamental regulator of embryonic development as well as tissue homeostasis. Consequently, the deregulation of its assembly, maintenance, or function leads to numerous human diseases, collectively termed ciliopathies. It has been estimated that cilia dysfunctions are responsible for as many as 100 human diseases. However, the mechanistic explanation of primary cilia assembly and function, crucial for the understanding of cilia-related defects and their therapeutic targeting, is insufficient.
Cilia-associted kinase termed TTBK2 has recently come up as a master regulator of primary cilia across vertebrates. The selected PhD student will pursue a project intended to investigate the molecular mechanisms governing the formation and maintenance of primary cilia, with focus on the role of TTBK2 and its downstream effectors.
Student pursuing this project will be a part of enthusiastic research team headed by Dr. Lukáš Čajánek. The student will have access to unique research tools, state-of-the-art methodology, and advanced instrumentation (cellular and animal models, proteomics, gene editing, lentiviral transduction, live cell imaging, super-resolution microscopy, etc.).

Requirements: Master's degree in biological sciences or similar.
The selected student should be motivated, curiosity-driven, eager to learn, and capable of critical thinking. Experience with cell biology techniques will be an advantage.

Requirements
Additional Information
Work Location(s)

Number of offers available

1

Company/Institute

Masaryk University, Faculty of Medicine

Country

Czech Republic

Geofield

Where to apply

Website

http://[email protected]

STATUS: EXPIRED