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. This project will extend those observations in engineered inducible malignant GCT cell lines in vitro which can, e.g., express miR-100-5p/miR-125b-5p upon doxycycline treatment. Combination treatment using miRNA
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of the Principal Investigator, the Research Support Associate will perform independent research within the lab. Studies include genetic modification of mammalian cells, in vitro reporter assays, and mutagenesis
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transcriptomics, proteomics and spatial profiling, followed by functional validation in human iPSC-derived in vitro cell-based models. The successful candidate will investigate complement-mediated neuroimmune
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Fruk (Department of Chemical Engineering and Biotechnology) and delivered to AT2 cells, using human alveolar organoids as the primary in vitro model. Working with the AstraZeneca team, drug selection
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de azucares, expresion y purificacion de proteinas en Pichia, fitopatologia, cultivo in vitro. (2) GraphPad, ImageJ. // (1) Theoretical and practical knowledge (experimental work and data analysis) in
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purification); in vitro/ex vivo mRNA delivery studies in cells, including primary patient cells; animal biodistribution studies using IVIS; in vivo studies of nanoparticle efficacy and toxicity in an animal
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-quadruplex- and i-Motif-forming DNA/RNA sequences to investigate their structural equilibrium, dynamics, and ligand, peptide binding interactome in vitro and in the intracellular space. The outcome will
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of novel therapeutics is highly desired. https://www.bcm.edu/research/research-centers/vaccine-research-center Job Duties Perform complex, advanced research under the general direction of the Principal
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of Staphylococcus species isolated from acute and chronic PJIs. AIM 3: To develop an in vitro platform to investigate the role of the agr quorum sensing (QS) system in biofilm formation, modulation of the immune
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the interactions among tumor cells,stromal cells,and the extracellular matrix using in vitro,ex vivo,and in vivo models.Particular attention will be paid to biochemical,biophysical,and structural alterations