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Field
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vitro to confirm the underlying mechanisms. This postdoctoral position will investigate how inflammation affects key molecular mechanisms, particularly serotonin and iron metabolism, and how these affect
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Sahoo and perform molecular/cellular studies of neuronal development using in vivo (mouse models) and in vitro (cultured primary neurons) models, involving skilled surgical procedures on mice and rats
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experience Relevant publications in the field Experience with in vitro (organoids), and in vivo (PDX) cancer models Demonstrated capacity for grant application Preferred areas of interest include, but
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not limited to bacterial sepsis, viral infections, and cancer. Candidate will perform in vitro and in vivo experiments and contribute to the laboratory research program. The candidate will organize
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-MS, NMR) and in vitro compound profiling. Familiarity with degron tags, CIP systems, or related proximity-inducing chemical biology tools (e.g. BromoTag, dTAG, HaloTag, AID). Who we’re looking for: A
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novel metabolic vulnerabilities in KRAS-mutant lung cancer using in vivo and in vitro screening approaches; (ii) validate identified targets in vivo and elucidate the underlying mechanisms; and (iii
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and perform assays using human cellular models aimed at validating the hypotheses and candidates prioritised within the project. Contribute to the development of human in vitro platforms (T1.2
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, survival analysis, longitudinal analysis, correlation analysis, clustering, dimensionality reduction, and predictive modeling. Conducts in vitro cancer biology experiments, including 2D culture, 3D organoids
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/ phenotypic / response output assays and biomarker detection /identification in vitro and in vivo. Determining immune cell responses via FACS, high content imaging microscopy, proteomics and transcriptomics and
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immunohistochemistry techniques. Develop hypotheses and experimental plans for in vitro and in vivo models. Trouble shoot and customize experimental tools, generate clear and timely records of experimental work. Review