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laboratory studies human brain development and neurodevelopmental disorders using human pluripotent stem cells, induced pluripotent stem cells (iPSCs), brain organoids, genetics, genomics, and molecular and
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neurodevelopmental disorders. The successful candidate will develop and apply experimental and computational approaches to understand gene regulation and disease mechanisms in neural development and to evaluate
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Templeton Foundation. The project seeks to discover and characterize novel RNA-based gene regulatory mechanisms in mammals, with a particular focus on riboswitches that sense lithium and sodium ions
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follow a bedside-to-bench template starting from gene variants already identified in human native and allograft kidney disease, to elucidating mechanisms via invitro tools to the development and/or
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. Writing Novel Genome Function: Design and validate synthetic sequences that promote cell-type-specific gene expression. Exploring Evolution & Human Health: Investigate how changes in the non-coding genome
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mammals, with the goal of revealing new mechanisms of gene regulation and cellular signaling. Position Overview The successful candidate will develop and apply advanced computational methods to identify
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models. Writing Novel Genome Function: Design and validate synthetic sequences that promote cell-type-specific gene expression. Exploring Evolution & Human Health: Investigate how changes in the non-coding
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Postdoctoral Associate | Mitochondrial Genomics | Lake Lab — Yale University, Department of Genetics
mutations shape cellular function, human health, and disease. Using cutting-edge approaches, the successful candidate will identify pathogenic variants, uncover factors that modify their effects across
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ASDs in humans to determine how disruption of these genes alters brain development and the neural circuits underlying simple behaviors. Our long-term goal is to use this gene-based approach to identify