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Density Functional Theory (DFT) calculations to model hydrogen-tramp element co-segregation at grain boundaries and phase boundaries Perform DFT to obtain atomistic insights into how tramp elements interact
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of newborn screening and the first gene therapies, affected children can increasingly be identified and treated before symptom onset. However, minimally invasive biomarkers are still needed to support early
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This doctoral project focuses on establishing isogenic iPSC-derived myelinating organoids as a physiologically relevant human in vitro model of Pelizaeus-Merzbacher-like disease type 1 (PMLD1). You will first
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of heterobispecific Fc format using protein engineering focusing on humanization and improved stability. Generation of high affinity minibinders for blood coagulation factors based on "in silico affinity maturation
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, using qualitative research, consensus methods and quantitative validation in an international cohort. Risk and resilience: identifying factors associated with parental distress, coping and resilience
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compositionally complex circular steels. As a PhD researcher, you will: Perform Density Functional Theory (DFT) calculations to model hydrogen-tramp element co-segregation at grain boundaries and phase boundaries
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advanced quantitative methods to uncover how psychological, social and economic factors shape vulnerability to gambling-related harm over time. As a PhD candidate, you will work in a highly interdisciplinary
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. The primary challenge lies in distinguishing genetic from epigenetic effects and establishing a causal relationship between DNA methylation variants and gene expression. In a collaborative project between
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damage development as a function of fatigue loading. The models will be implemented and validated in commercial finite element (FE) software. The resulting FE model will define the digital twin
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University Medical Centers. Sanquin is strategically located in Amsterdam, with a special tie to the Amsterdam UMC (Joint Landsteiner Laboratory). This project focuses on developing coagulation factor mimetics