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Field
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-sputum whole-genome sequencing within the DiSrupT RR-TB trial. The clinical trial will evaluate a multi-component intervention to reduce the transmission of RR-TB. A key component of the intervention is a
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programmable nucleic-acid systems that sense defined human genomic sequences and convert those molecular recognition events into engineered DNA outputs. The broader aim is to develop molecular systems in which
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offers a vibrant scientific community and outstanding core facilities to support advanced genome engineering, imaging, and high-throughput sequencing. How to Apply Please submit the following materials
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-genome sequencing. You will possess strong analytical, problem-solving, and data interpretation skills, with the ability to work both independently and collaboratively within a multidisciplinary research
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: Design and execute experiments using primary human endothelial cells. Prepare and QC sequencing libraries including bulk RNA-seq, small RNA-seq, ATAC-seq, and single-cell libraries. Perform genome-scale
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Responsibilities Conduct genomic analyses, including whole-genome sequencing and transcriptomics, to study structural variations, recombination events, and sub-genome interactions. Perform cytogenetic experiments
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origin mapping, translocation-capture sequencing and 3D genome architectural analyses, supported by our established in-house computational pipelines. Interested candidates should hold a PhD, or be close
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at the Blizard Institute, Queen Mary University of London, with close collaborations across Barts Health NHS Trust and Imperial College London, you will work at the interface of genomics and antimicrobial
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project 1. Only 2% of the human genome sequence codes for proteins, while most of it consists of noncoding sequences, including regulatory factor binding regions, transposable elements, pseudogenes
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, from long-read DNA sequencing data and Hi-C. Will also annotate the genome. Additional genomic analyses enabled by the dataset at hand and by accessing other public datasets (e.g. comparative genome