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, lethal, hard-to-cure brain tumor. Accumulating evidence points to extensive tumor heterogeneity, as well as plasticity in response to therapy, leading to therapy failure. At the single cell level, this
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toxicosis (pre-eclampsia) based on methylation changes in cell-free DNA in the maternal bloodstream (which partly originates from pregnancy). The other part, which would constitute your assignment, deals with
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on the interaction of mycotoxins and the gut epithelium towards colorectal cancer risk using mouse and patient-derived gut organoids, in vitro cell assays, conditional mouse model of colorectal cancer and patient
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computer power. Depending on the interest of the candidate, the student will work on one of the following topics: Developing new methods for simulations of drug transport through cell membranes, building up
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of the candidate, the student will work on one of the following topics: - Developing new methods for simulations of drug transport through cell membranes, building up from membrane permeability calculations
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: Biochemistry and Biotechnology or Doctor of Science: Biochemistry or Doctor of Science: Biology or Doctor of Applied Biological Sciences: Cell and Gene Biotechnology or Doctor of Health Sciences or Doctor
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pathophysiological processes leading up to the cardiovascular manifestations associated with Marfan syndrome. Our latest results indicate that immune cells play a role in the early development of thoracic aortic
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project, we will use a powerful combination of in vivo experimental COPD models and ex vivo analysis of primary human tissues and cells to comprehensively delineate the roles of TLR7 and elucidate
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lecturing; Professionalisation of education; Experience with animal experiments; Experience with alternatives for animal experiments (e.g. explants, primary cell cultures); Experience with both basic (e.g
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, leading to therapy failure. At the single cell level, this presents with different cell states that can transition into one another upon specific environmental conditions or treatment. A comprehensive