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German Cancer Research Center in the Helmholtz Association (DKFZ) | Oettingen in Bayern, Bayern | Germany | 2 months ago
transcriptional and epigenetic regulation of enhancer networks shapes gene expression programs that drive tumor progression, metastasis and therapy response in small cell lung cancer. By combining mechanistic
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response, making prognosis and therapeutic decision-making particularly challenging. Epigenetic mechanisms are believed to play a key role in neuroinflammation and neurodegeneration processes, and a better
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or perhaps epigenetic changes. This project will investigate the phenomenon using the rice blast fungus Magnaporthe (Syn. Pyricularia) oryzae, which destroys enough rice each year to feed 60 million people
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on the overall organisation of chromatin. 3. The study of their consequences on cell survival and gene expression. Ultimately, this work aims to provide an in-depth understanding of the epigenetic and
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evolution in Miscanthus hybrids, and to investigate how regulatory, epigenetic, and structural mechanisms contribute to the balance or dominance among subgenomes. Miscanthus is a notable bioenergy crop
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to develop a new class of therapeutics based on bottom-up Synthetic Immunology. Inflammatory signals lead to epigenetic remodeling that can impact subsequent immune responses. This innate immune memory is
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Foundation. About the project/work tasks: The project focuses on early epigenetic aberrations occurring during embryonic development, and resulting in increased risk of cancer in adult life. The overall aims
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of genomics, epigenetics, molecular, cell and developmental biology, biochemistry, bioinformatics and immunology, with a focus on the normal and pathological development of the child. Doctoral candidates are in
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biology and epigenetics, RNA biology, computational biology, and genome analysis. All these topics by their very nature depend strongly on the connection between experimental and computational work. Course
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areas include: DNA Damage & Repair Genetics & Epigenetics Immunology & Inflammation Membrane & Lipid Biology Metabolism & Nutrient Sensing Mitochondrial Biology Neuroscience & Neurodegeneration Protein