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investigate the impact of post-transcriptional modifications of transfer RNAs (tRNAs) on stress tolerance and adaptation in clinical strains of *Escherichia coli*. The project will combine experimental
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are needed to prevent infections with bacterial enteropathogens and AMR. Our previous research showed that there are differences in the E coli colonization of infants’ microbiome between LMIC vs. high-income
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person to join our team. Core topics to work on: (1) In vitro assays to determine inhibitor efficacy against redox membrane proteins (2) Cysteine enrichment of DsbA substrates in E. coli and Mycobacteria
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biology, microbiology, biochemistry, molecular biology, or a related field Experience working with yeast cultures and their transformation Experience working with microorganisms, molecular cloning, and E
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experience in molecular biology methods, including E. coli culture, cloning, PCR, gel electrophoresis, and analysis of Sanger DNA sequencing results Targeted experience in basic immunological methods, such as
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Responsibilities: Design and engineer novel recombinant proteins with tailored mechanical or functional properties. Manage high-yield protein expression (E. coli or alternative hosts) and multi-step chromatographic
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sensitivity, on resistance evolution. As model pathogen, we will focus on UTI E. coli and/or lung-infecting Pseudomonas aeruginosa. As a general reference, check out the group’s publications on AMR evolution
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topics to work on: (1) In vitro assays to determine inhibitor efficacy against redox membrane proteins (2) Cysteine enrichment of DsbA substrates in E. coli and Mycobacteria using proteomics. (3) determine
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Molecular Biology at Penn State. The candidate in this position will study transcription and/or post-transcriptional regulatory mechanisms in B. subtilis and E. coli . Experience in gene regulation, in vitro
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laboratory work in recombinant protein expression in different platforms such as E. coli, yeast, protein analysis such as SDS-PAGE, Immunological assays such as ELISA, Western blot. Recombinant protein