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investigate the impact of post-transcriptional modifications of transfer RNAs (tRNAs) on stress tolerance and adaptation in clinical strains of *Escherichia coli*. The project will combine experimental
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*, Shigella*, and pathogenic E. coli. The group is interested in defining the mechanisms of pathogenesis and the mechanisms of plasmid biology with the long-term aim of applying these findings
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Molecular Biology at Penn State. The candidate in this position will study transcription and/or post-transcriptional regulatory mechanisms in B. subtilis and E. coli . Experience in gene regulation, in vitro
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, identification, and confirmation methods for foodborne pathogens such as Shiga toxin-producing E. coli, Salmonella, Listeria monocytogenes, and Campylobacter. Develop an understanding of analytical challenges
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include expressing recombinant proteins in insect, mammalian, and E. coli cells; purifying proteins using FPLC systems; performing in vitro RNA transcription and labeling; carrying out in vitro assays
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antimicrobials to inactivate pathogens such as Salmonella spp., E. coli, L. monocytogenes in food products (eggs, fruits and vegetables, nuts) and food-contact surfaces. The control of foodborne pathogens without
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this subgroup focuses on the development of rapid, field-deployable detection methods for specific foodborne pathogenic bacteria (e.g., Shiga toxin-producing E. coli, Salmonella, Listeria monocytogenes). Analysis
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. The candidate in this position will study transcription and/or post-transcriptional regulatory mechanisms in B. subtilis and E. coli . Experience in gene regulation, in vitro transcription, RNA biochemistry
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Other Position Time Status Full-Time Required Education Ph. D. in chemistry, biochemistry or closely related field. Required Related Experience Culture of E. coli, sterile technique, protein purification
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Proteomics and Cell assays. Candidates with mostly Synthetic/Medicinal Chemistry training are discouraged from applying. Experience in protein purification from E. coli will be considered favorably, but not