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Field
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an excellent fit for you! In this ZonMw-funded project (called UnStreZ), you aim at unraveling the mechanisms of DNA replication stress and genomic instability in zygotes with the ultimate aim of improving
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/maelfait-lab Research Project Nucleic acids are potent triggers of immune responses. The presence of virus-derived RNA or DNA molecules activates nucleic acid sensors inside the host cell, which stimulates
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of collective excitations, energy transfer in DNA origami structures, and ultrafast atomic forces. • Sharing your results in scientific publications and at international conferences. • Strengthening global
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of the supervisory team, including Dr Lisiane Meira , an expert of DNA damage and its impact in cancer and chronic diseases, and external collaborators. Supervisors:Dr Maria Teresa Esposito and Dr Lisiane Meira Entry
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of Medical Biology, PAS. The antiviral activity of the synthesized compounds will be evaluated against a panel of clinically relevant DNA and RNA viruses, including herpes simplex virus type 1 (HSV-1), HPIV-3
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tumor cells, cell-free DNA, extracellular vesicles) Familiarity with single-cell omics methods (scRNA-seq, proteomics) Basic bioinformatics skills (R, Python, or similar) Experience working with patient
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differentiation, gene editing in vitro and in vivo. The specific techniques include, but are not limited to, cell culture, flow cytometry and cell sorting, DNA/RNA/protein extraction and quantification, histology
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limited to, cell culture, flow cytometry and cell sorting, DNA/RNA/protein extraction and quantification, histology, microscopy. The desired candidate must have expertise in human cell culture and aseptic
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the CV and/or in the motivation letter; Experience in disease mechanism, particularly in oxidative stress and DNA damage responses - information provided in the CV and/or in the motivation letter
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preparation of in-house DNA/RNA sequencing libraries or microbiome science, including 16SrRNA metabarcoding, metagenomics, isolation and culture. Prior analysis of high-throughput sequencing data and experience