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to projects involving: multi-omics analyses (single-cell, cell-free RNA/DNA, methylation, proteomics); biomarker discovery for pregnancy complications and neonatal outcomes; computational biology, machine
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(alternative splicing and DNA methylation) to refine the prognostic stratification of IDH-wildtype Glioblastoma. The activity includes: 1) In silico bioinformatics analysis on public datasets and data
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. The employee will perform all aspects of DNA isolation, mutation detection in human disease associated genes, real-time Q-PCR analysis for gene dosage and mosaicism analysis, NGS library preparation, sequence
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genome architecture is DNA methylation, which is regulated, among others, by TET enzymes. Altered TET1 activity has been observed in many cancers, but its consequences remain poorly understood. Our
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, or computational analysis of clinically annotated cancer datasets. Experience with multi-omics data integration, including DNA sequencing, bulk and single-cell RNA sequencing, spatial transcriptomics, methylation
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modifications, DNA methylation and gene regulation. Hands-on experience with molecular biology techniques, such as DNA/RNA extraction, qPCR, RT-qPCR and next-generation sequencing (NGS)-based approaches
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for treatment or early intervention. To this end, we integrate genetic studies with gene expression and epigenetic marks (e.g., DNA methylation, chromatin accessibility) in cells that are relevant to asthma and
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and DNA methylation studies. 3. Maintain accurate laboratory records, study databases and sample inventories in accordance with University policies and good research practice. 4. Analyse and interpret
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. To do so, the researcher will notably analyze bulk and single-cell multi-omics datasets (gene expression, DNA methylation, chromatin accessibility, transcription factor binding, and others) from mouse and
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, and the NCI, and has extensive collaborations with the McDonnell Genome Institute. Position will play a lead role in new studies of epigenetics, DNA methylation, and gene regulation in acute myeloid