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how super-enhancer dysregulation contributes to B-cell acute lymphoblastic leukaemia. The project applies sophisticated gene editing techniques such as CRISPR together with CUT&Tag and ATAC-seq
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function. Over the years, SBS has attracted talented individuals from around the world and Singapore to join as scientific leaders and researchers. For more details, please view https://www.ntu.edu.sg
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enabling transcriptional recovery. The project will be focused on understanding how the ASCC3 lncRNA regulates RNAPII-mediated transcription and its recovery after DNA damage, using CRISPR/Cas9 technologies
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. · Investigation of structural variants that alter gene regulation or disrupt noncoding genomic loci. · Development of cellular models for studying candidate disease mechanisms. · CRISPR /Cas
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expertise in cell biology, genome engineering, CRISPR -based screening, functional genomics, or C. elegans genetics are particularly encouraged to apply. Minimum Education and Experience Ph.D in a
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position will require mammalian cell culture and associated techniques like CRISPR/Cas9 gene expression control, pharmacological treatments, transfection, cloning, and cell passaging. Experiments will
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characterization techniques, proficiency in molecular biology techniques, including PCR, Western blotting, immunofluorescence, and flow cytometry, familiarity with gene editing tools (e.g., CRISPR/Cas9
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with both experimental mice and human cells. Flow cytometry, cell signaling, and CRISPR screening assays will be integral to the research. The employee will split time ~10/90 between lab management and
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understand how genetic variation shapes biological function. At the heart of our research is MAGESTIC ( https://doi.org/10.1038/nbt.4137 ), a CRISPR-based technology that enables precise engineering of
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, CRISPR Core, and Proteomics Core. Together, these facilities offer a broad range of expertise and provide excellent opportunities for conducting ambitious research projects efficiently. Within the