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Field
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engineering and immunological assays, large-scale high-throughput screening approaches (CRISPR screen, drug screen, etc.) and in vivo preclinical models to study interactions between cancer cells and
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hematopoietic malignancies and develop novel therapeutic strategies. Position Responsibilities The Lab utilizes a combination of CRISPR/Cas functional genomics and metabolomics as well as optogenetics and fiber
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are currently using include: organoid culture, CRISPR genome editing, CUT&RUN/ChIP, scRNA-seq/scATAC-seq, 3D imaging/expansion microscopy, proteomics, and mathematical modeling. IUSM is committed to being a
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: protein biochemistry, enzyme kinetics, coagulation assays, recombinant protein expression ● Molecular biology: gene expression analysis, RiboTag/RNA-seq, CRISPR, cloning ● Cell biology
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, tumor immunology, etc.). Utilize molecular and cellular biology techniques such as CRISPR/Cas9 gene editing, flow cytometry, RNA sequencing, and imaging technologies. Analyze and interpret experimental
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Center for Biologics Evaluation and Research (CBER) | Silver Spring, Maryland | United States | about 10 hours ago
therapeutic applications. The specific focus will be immune responses to Cas proteins used in gene editing. Cas9 proteins derived from human pathogens are the most extensively studied CRISPR-Cas gene editors
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antibody-based approach to intervene the malignancies 3) Identification of novel therapeutic target using high-throughput CRISPR genetic screen (e.g., metabolic pathway, mitochondria structure) in immune
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, protein engineering, and synthetic biology tools (e.g., CRISPR, metabolic pathway design). Ability to work independently, solve complex problems, and manage multiple priorities in a fast-paced research
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; Molecular perturbation (CRISPR, RNAi, etc.) Preferred qualifications Background in BRCA1, HMMR, PLK1, or related mitotic regulators Experience in epithelial polarity or tissue architecture Quantitative
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engineered systems; Primary cell culture or organoid systems; Molecular perturbation (CRISPR, RNAi, etc.) Preferred qualifications Background in BRCA1, HMMR, PLK1, or related mitotic regulators Experience in