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Description The postdoctoral researcher will investigate how intrinsically disordered regions and short linear motifs regulate protein interactions and cellular organization. The project will focus on protein
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in the growth of melanoma cell xenografts in isogenic mice; to determine how GATA6 modulates the tumor immune microenvironment (immunohistochemical staining of tumor sections, transcriptomic analyses
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the experimental and bioinformatics analysis components—is essential. Proficiency in classical genomics techniques (RNA-seq, ChIP-seq, etc.) Proficiency in mouse ES cell culture and in vitro differentiation
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, integrating statistical inference, machine learning, and population genetics. We will develop advanced computational methods to characterize the functioning of T- and B-cell repertoires. The goal is to build
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proficiency in techniques for quantifying inflammatory markers, including ELISA and related assays. Extensive experience in histology and immunohistochemistry, together with a proven track record in cell
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analyses from various 2D/3D cell models. He/She will produce and characterise peptides derived from the extracellular matrix. He/She will analyse the results and contribute to their application. He/she will
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and fabricating transparent and flexible microelectrode arrays (MEAs) based on conductive polymers for recording the electrical activity of enteric neuronal networks, as well as for performing cellular