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intercellular communication across difference systems, with a focus on how changes in metabolic and redox states are sensed by the phosphotyrosine machinery in cells. We are looking to welcome a new ERC-funded
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the molecular mechanisms of nucleotide metabolism and cancer therapies. The candidate will work with cell culturing and state-of-the-art technologies including genome-wide CRISPR screens, CRISPR genome editing
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project focussed an essential bacterial cell division protein complex from Streptococcus pneumoniae. The goal of this project is to understand the mechanism of action and control of the PcsB peptidoglycan
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to the clinic. Our team uses innovative models and techniques to investigate the mechanisms that enable cancer cells to evade chemotherapy, including the role of the bone microenvironment. We publish our work in
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group that the cryptochromes regulate voltage gated sodium channels in pain sensory nerves. Through better understanding of the mechanism, we aim to progress to development of drugs that can safely reduce
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understanding regulatory mechanism regulating cell fate specification, cell cycle remodeling during cellular differentiation and the interplay between metabolism, cell cycle and cell fate. There is a strong focus
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Location: The Francis Crick Institute, Midland Road, London Short summary Julian Downward’s laboratory (Oncogene Biology) investigates the mechanisms by which mutant oncogenes drive the formation
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of the project include: (1) Develop innovative methodologies for constructing synthetic cells with membrane architectures, and intracellular machinery; (2) Investigate strategies for incorporating biomimetic
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Working with organoid models to understand mechanisms in familial interstitial lung disease. Dr Dickens and the Marciniak Group are seeking a postdoctoral fellow to drive innovation in a programme
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homeostasis and disease with a focus on skin and the melanocyte lineage. We use live imaging of cells and tissues and biosensors of cellular processes such as cell cycle progression combined with mathematical