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in cell lines, co-cultures, and mouse models to study intrinsic and extrinsic mechanisms mediating tumor progression. Develop model systems and employ novel methodologies to elucidate the underlying
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laboratory team to investigate disease mechanisms and the impact of novel drugs using human induced pluripotent stem cell (iPSC)-derived neuronal models. The role will primarily involve the maintenance and
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Medical Center in Dallas, Texas, investigates the molecular mechanisms by which pathogenic bacteria manipulate host cell signaling and immune responses. The lab's research integrates microbiology
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and immune function. By understanding these mechanisms, we aim to identify new opportunities for targeted therapeutic intervention. Bringing together chemical biologists and protein, antibody, and cell
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Inria, the French national research institute for the digital sciences | Villeurbanne, Rhone Alpes | France | 5 days ago
on the identification of molecular mechanisms associated with tumor cell plasticity. Tumor cell plasticity refers to the ability of cancer cells to alter their transcriptional programs in response to environmental cues
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About the lab The Laboratory of Causal Systems Immunology combines causal inference, probabilistic AI and large-scale in vivo perturbation experiments to uncover how genes shape immune-cell states
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." • Develop and apply human pluripotent stem cell-derived kidney organoid models, CRISPR-Cas9 genome editing, and molecular and cellular biology techniques to investigate disease mechanisms. • Perform and
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Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis https://pubmed.ncbi.nlm.nih.gov/31348891/ The landscape of immune dysregulation in Crohn's disease revealed through single-cell
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-extrinsic mechanisms of resistance to KRAS inhibition, including fibroblast-mediated mechanisms, across genetically distinct PDACs. We will prioritise PDAC genotypes for which we already have preliminary data
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-dimensional scaffolds using FDM 3D printing for cell culture applications. Develop and optimize biomimetic materials with controlled mechanical and biochemical properties. Functionalize scaffolds with