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stress affects specific cell types in the nervous system and the gut, using human pluripotent stem cell (hPSC)-derived models of the enteric nervous system. Our work sits at the intersection of stem cell
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cancer development, progression, and metastasis. The successful candidate will combine advanced cell and tissue culture methods with bioengineered model systems, quantitative microscopy, and molecular
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following techniques: mammalian cell culture, bacterial culture and growth assays, fluorescence and confocal microscopy, molecular cloning, genetic manipulation of mammalian cells and bacteria, quantitative
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following: - Mouse models, mouse breeding, and animal surgery - Histology and immunohistochemistry - Cell culture and stem cell biology - Molecular biology techniques (PCR, cloning, Western blotting) - Flow
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experience with mammalian cell culture, protein expression (E. coli, yeast, and mammalian cells) and purification, and/or Drosophila genetics, including dissection, immunostaining, and confocal microscopy
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in the first instance, with possible extension thereafter. We are looking for a talented ambitious postdoctoral researcher to join a Cancer Research UK-funded programme to examine the role of cell
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to therapeutic validation and publication. About You You will already or shortly hold a PhD in cancer/molecular biology or a related discipline. Substantial hands-on experience in mammalian cell culture and
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culture techniques. Skilled with common laboratory techniques and equipment consistent with PhD-level graduate training. Ability to commit to an independent scientific career in stem cell biology
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. Experience in planning and executing experimental work in three or more of the following areas: chromatin/epigenetics (e.g., ChIP-seq, CUT&RUN/CUT&Tag, chromatin fractionation), stem cell culture and
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or immunology Hands-on experience in flow cytometry, cell sorting, 10X 3’scRNAseq Proficency in primary hematopoietic cell culture Proficency in hematopoietic transplantation experiment Experience in animal