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Field
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with experience of advanced genome editing including cloning of CRISPR gRNAs for custom screens, base editing (including alternative specificity Cas enzymes) and prime editing. Experience of off-target assays
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underlying neutrophil-mediated resistance to anti-PD-1 immunotherapy Metabolic and functional reprogramming of neutrophils during cancer progression Novel therapeutic strategies targeting tumor–myeloid
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understanding of the key molecular targets in cancer metabolism and translate it to the clinic. This position provides the opportunity of strong mentorship and a close, multidisciplinary collaborative research
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, Z. F. Confidence as Bayesian Probability: From Neural Origins to Behavior. Neuron 88, 78–92 (2015). 3. Foucault, C. & Meyniel, F. Two Determinants of Dynamic Adaptive Learning for Magnitudes and
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vulnerabilities in drug resistant, KRAS- and EGFR-mutant NSCLC and inform the development of ferroptosis-targeted treatments to improve treatment outcomes and survival for patients with lung cancer. Location
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(KCL), the post holder will investigate the biology of regulatory T cells (Tregs) to identify the most suppressive Treg subsets within IBD gut lesions - informing targeted strategies for restoring immune
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of neural networks, information-theoretic and optimal-transport perspectives on representation and generalisation, probabilistic numerics and Bayesian deep learning, and emerging frameworks for scientific
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specific, targeted, precise genome edits in a range of insect species. We aim to start in a model insect, likely Drosophila, then move on (project year 2) to insect pollinators. The project and position
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Establish MS-based biomarkers for target engagement and clinical studies Analyse datasets in Python/R; publish and mentor students What we offer Ownership of the LRRK2 workstream within a major international
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keeping Risk management Target Compensation Maximum: $81,529.00 Target Compensation Minimum: $54,318.00 Compensation will be commensurate to candidate experience. Equal Employment Opportunity The University