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cells including macrophages). - Modelling of CKD-like vascular injury in 3D vascular organoids derived from induced pluripotent stem cells (iPSCs), exposed to phosphate, uremic toxins and pro-inflammatory
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strains) and assess their role in CaCO3 dissolution, before and after pressurisation. • Develop and run multiphysics numerical models in COMSOL (3D geometries from tomography, transport–reaction coupling
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have access to state-of-the-art facilities, including cleanroom microfabrication, laser micromachining, 3D printing, advanced microscopy, and numerical modeling tools. The project benefits from a close
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will be to connect 2D generation with the production of usable 3D models, while maintaining an explicit link between visual hypotheses and documentary sources. A third phase will consist in formalizing a
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effects, such as 2D/3D propagation and beam speckle patterns, which remain largely unexplored because they require significant simulation capabilities. This thesis aims to conduct a systematic kinetic
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photolithography, 3D printing and multiphoton lithography, together with innovative biomaterials. These models will be used to investigate, through advanced microscopy and quantitative image analysis, how
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. The project will combine hydrogel formulation and characterization, microfabrication, 3D cell culture, advanced microscopy, and functional biological analyses. Particular emphasis will be placed on developing