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reconstituted telomeric system to determine how Shelterin orchestrates multiple telomere activities from the single-molecule to cellular level. This approach will for the first time directly observe telomeric DNA
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pharmacology), Prof. Joe Harrity (organic chemistry), and Dr. Tim Craggs (single-molecule FRET and biophysical techniques). The project aims to: 1. Design, synthesize, and characterize fluorescently labelled
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round Details When proteins are synthesised (using a natural or cell-based method), they are contaminated with hundreds of other proteins, nucleic acids and numerous other small molecules. At the moment
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