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, collaboration with other institutions through visits, learning techniques and skills, and attending workshops and conferences to present research findings. Project overview Previously we have shown a genetically
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(https://www.sheffield.ac.uk/smph/people/neuroscience/andrew-grierson). Expansions of a noncoding GGGGCC hexanucleotide repeat in the C9ORF72 gene are the most common genetic defect found to date in
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, vegetable and seed crops for human consumption: over 65% of the top world crops are at least moderately dependent on animal pollinators. Pollination is also crucial for sustaining healthy, genetically diverse
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established cellular and genetic assays to validate findings in vivo. Finally, we will characterise cancer and ageing associated mutations to understand how they dysregulate telomere function. References
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sequencing to identify genetic variants associated with familial Bell’s palsy. We will recruit a UK wide cohort of individuals with familial Bell’s palsy. This will be done via both NHS clinics and the patient
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editing therapy for blood disorders. Objectives Our ultimate goal is to progress AAV9 base genome editing therapeutic strategies for genetic disorders affecting the central nervous system (CNS). Specific
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mechanisms by which primary cilia control muscle regeneration remains to be elucidated. This project will use the power of mouse genetic models allowing us to selectively eliminate primary cilia in skeletal
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developed Drosophila and zebrafish models of NMIHBA. You will use genetic approaches to determine which cell types are involved in the seizure phenotype. You will then use fluorescence microscopy
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inactivated viruses. Because they lack viral genetic material, they cannot replicate or cause disease in the host. This makes them a safe and effective platform for vaccine development. In this project
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. This project uses zebrafish as a model to identify the signals that recruit regenerative cells to the site of injury. Genetic and pharmacological inhibition of signalling pathways will be used to identify key