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Fluorescent Labelling of Protein Hormones Interacting with Class B G Protein-Coupled Receptors: Insights into Ligand-Receptor Dynamics and Signalling School of Medicine and Population Health PhD
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photosensitisers to answer this question. Training: You will master ultrafast optical spectroscopies (transient absorption, infrared, fluorescence) in the Lord Porter Laser Laboratory at Sheffield, where
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hypothesise that the innate immune system plays key roles in the instigation of heart infections that can be therapeutically manipulated to improve infection outcomes. You will use state-of-the-art fluorescence
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collect comprehensive field data describing river bathymetry and velocity distributions, together with concentration distributions obtained from fluorescent tracer studies. This field work will also provide
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vivo, fluorescent imaging, you will carefully examine the cell biology of immune-damaged cell interactions at these sites of damage. This careful characterisation will further inform and develop our
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Fluorescent Labelling of Protein Hormones Interacting with Class B G Protein-Coupled Receptors: Insights into Ligand-Receptor Dynamics and Signalling
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of high throughput automated, quantitative drug screening (Sheffield Zebrafish Screening Unit). We have extensive experience of different drug screening assays using gene expression and fluorescence read
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developed Drosophila and zebrafish models of NMIHBA. You will use genetic approaches to determine which cell types are involved in the seizure phenotype. You will then use fluorescence microscopy
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profiles (OH and potentially NH and NH2) through the diffusion flame can be determined using a planar laser-induced fluorescence technique. These experiments will provide data to enable the validation and
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’ of these fragments that will allow the incorporation of functional molecules such as fluorescent reporters. [email protected] https://www.sheffield.ac.uk/chemistry/people/academic/joseph-pa-harrity