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. EVs contain macromolecules, such as mRNA and proteins, and can be engineered to be loaded with different types of cargo, such as mRNA, siRNA and CRISPR/Cas9. Here they will be used to delivery editing
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, 2020; Shaw, Lundin, et al, Nat Methods 2014). In this project, the postdoctoral research fellow will investigate the nanoscale spatial organization of insulin receptors in different tissues
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shown that human white adipose tissue contains three distinct adipocyte subtypes. In this project, we aim to understand from which progenitor cells they are formed. To achieve this, we will employ several
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a unique automated robotic lab for high-capacity full-length scRNA-seq that can provide state-of-the-art splicing information across complex tissues. Using this scalable scRNA-seq technology, we
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technology (Spatial VDJ). Using established and newly developed algorithms, we map B cell evolution within tissues, including class switching and somatic hypermutation, and identify putative candidate tumor
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for characterizations. The group also consists of a clinical unit that performs skin biopsies for generation of induced pluripotent stem cells as well as collection of tissue and brain imaging for in vivo validations