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genomics and advanced experimental models to determine to what extent in vitro stem cell systems mimic the variety of molecular programmes underlying the emergence of hematopoietic cells at multiple
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Duties & Responsibilities: Information on being a postdoc at WashU in St. Louis can be found at https://postdoc.wustl.edu/prospective-postdocs-2/ . Additional information can be found at: https
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). Many MN arise from clonal haematopoiesis (CH)—the abnormal expansion of blood stem cell clones carrying somatic mutations. Haematopoietic stem cells interact with bone marrow adipose tissue (BMAT
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with these rare but severe disorders. Using a combination of disease model systems such as induced pluripotent stem cell-derived hematopoietic stem cells and engineered hematopoietic stem cells from
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using stem cell–based embryo models. The successful candidate will contribute to projects focused on engineering and characterizing embryonic stem cells, assembling 3D embryo-like structures, and
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using stem cell–based embryo models. The successful candidate will contribute to projects focused on engineering and characterizing embryonic stem cells, assembling 3D embryo-like structures, and
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models to determine to what extent in vitro stem cell systems mimic the variety of molecular programmes underlying the emergence of hematopoietic cells at multiple anatomical locations and timepoints in
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, nanoscale materials), mammalian cells (e.g. immune cells, stem cells) and microbial cells, multicellular organoid systems (New Approach Methodologies, NAMs), as well as other systems for biomedical
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cardiometabolic syndrome affects heart muscle cells. As part of the project, you will develop and apply innovative models based on human stem cells and bioengineered cardiomyocytes to investigate and
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models. The successful candidate will contribute to projects focused on engineering and characterizing embryonic stem cells, assembling 3D embryo-like structures, and performing molecular and imaging