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molecular mechanisms underlying neurodegeneration remain poorly understood at the protein level. Patient-derived induced pluripotent stem cells (iPSCs) provide a unique window into disease-relevant biology
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://www.guermonprezlab.org ). There is strong evidence that some populations of CD8+ cells like tissue resident memory-like (TRMs) or poorly differentiated stem-like T cells (TSL) are associated with favorable clinical
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; Jacob et al., Cell Stem Cell 2022; Di Carlo et al., Nature Immunology 2023). Building on these findings, we aim at identifying novel mechanisms regulating the tumor microenvironment and antitumor immunity
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challenges in stem cell research, aging and disease modeling. The group employs methodologies from different areas of mathematics, engineering, and physics, and integrates multiple sources of biological