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College of Health, Medicine and Life Sciences Funding for the Executive Dean’s PhD Studentship: Lineage tracing of blood stem cell development in embryo-like gastruloids College / Directorate
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College of Health, Medicine and Life Sciences Funding for the Executive Dean’s PhD Studentship: Lineage tracing of blood stem cell development in embryo-like gastruloids The team of Cristina Pina
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kingdom, can enter stem cells to influence the formation of complex tissues. This is important because stem cells play a major role to generate all other specialized cell types in the human body. By
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anxiety. It occurs when tissue from the uterus grows outside of the womb, causing inflammation and abnormal blood vessel growth. Special types of cells called fibroblasts and mesenchymal stem cells play a
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essential in the maintenance of skeletal muscle health. The ability of skeletal muscle to respond to stimuli such as exercise, injury and trauma, is in part, due to muscle resident stem (satellite) cells
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techniques with CRISPR/Cas9 genetic editing technology of hPSCs and primary cartilage cells. Together, this studentship offers an exciting opportunity to couple stem cell biology with genetic engineering and
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establishing stem cells from human cord tissues, extracellular vesicles isolation and induced pluripotent stem cell (iPSC)-culturing and differentiation. The PhD candidate will also experience working as part of
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PhD Studentship: The Role of the Extracellular Matrix in Cardiomyocyte Developmental (SMITH_U24DTP1)
in cardiomyocytes. This project will use state-of-the-art gene edited pluripotent stem cell models, to gain new insights relating to the mechanisms involved in regulating cardiomyocyte function
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heat stress in cattle and pig pre-hatching (elongation) embryos. (2) Establish consequences of such effects on cell fate in gastruloids formed from stem cells derived from control or heat-stressed pig
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gastruloids formed from stem cells derived from control or heat-stressed pig blastocysts. A range of temperatures (representing extremes of core-body temperature) will be assessed during in vitro embryo culture