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. In this PhD project you will further develop a model based on human induced pluripotent stem cells that differentiates to functional neuronal networks in vitro. In addition, you will perform a
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research program of the UMC Utrecht Brain, Circulatory Health, or Regenerative Medicine and Stem cells Research Centers . Requirements Specific Requirements A PhD in a relevant field (Biotechnology
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/tasks of the PhD student: Human stem cell culture Differentiation of stem cells to cardiomyocytes and fibroblasts Preparing 3D engineered heart tissues Analysing mechanical behaviour (stiffness
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microscopy, CRISPR-CAS gene editing, and work in close collaboration with PhD student and bioinformaticians. The candidate will be embedded in the research group of Prof. dr. M. Drukker, focused on stem cells
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organoid systems, such as kidney and intestinal organoids as well as stem cell-derived embryo models. Stem cells, including induced pluripotent stem cells, demonstrate an impressive self-organizing capacity
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of RIMLS-Science include epigenetics, stem-cell and developmental biology, and computational biology. The central research theme is regulation of gene expression during development, in health and in disease
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. The overarching aim of RIMLS-Science is to decipher molecular mechanisms of disease. Research areas of RIMLS-Science include epigenetics, stem-cell and developmental biology, and computational biology. The central
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of your PhD, you write a PhD thesis, which you will defend in an oral exam/celebration. You will likely encounter the following techniques during your PhD: Culturing blood cells and induced pluripotent stem
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assess this both in human cancer cell lines and mouse developmental models (mouse embryonic stem cells and gastruloids). The project, led by Dr. Rutger Gjaltema, is embedded in the Molecular & Cellular
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embryonic stem cells and embryo models. Responsibilities We are looking for a candidate that will develop an independent research line to elucidate the role of cohesin in gene regulation. In this context