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cells (Bartok et al., Nature 2021; Champagne et al., Molecular Cell 2022; Pataskar et al., Nature 2022; Yang., Molecular Cell 2024). In a project awarded by ERC-AdG-2024 for five years, the Agami group
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aims to understand the processes that act to safeguard genome integrity but that, when working inappropriately, cause cells to become dysfunctional or die, or to get derailed and cancerous. More
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cells and budding yeast. We will take advantage of CRISPR-mediated approaches, high-throughput analysis of DNA regulatory regions, novel tRNA sequencing methods, and innovative strategies to decode
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