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: Ridone, P., Vassalli, M. & Martinac, B. Piezo1 mechanosensitive channels: what are they and why are they important. Biophys Rev 11, 795–805 (2019). https://doi.org/10.1007/s12551-019-00584-5 . Lüchtefeld
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populations within the TME are relevant to tumour evolution and patient survival outcomes [2-4]. This PhD project will seek to investigate the prognostic value of spatial immunophenotypes in lung cancer
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that contribute to the development and maintenance of these conditions. These projects will use a variety of molecular, cellular and systems level techniques to study somatosensory circuits in rodent models and
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highly relevant to the study of inflammatory disease, as well as the development of new therapies such as vaccines and immunotherapies. Summary aim: This project will investigate the regulation of human
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, metabolism, development, regenerative biology, and behavioural science. MSc (Research): 1 year full-time; 2 years part-time; Apply now Research projects Research projects Assessing the activity of novel
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accumulation of mutant collagen IV is associated with disease development, and that treatment of collagen IV mutant cells can reduce ER-stress (2). This provides a golden opportunity to identify the disease
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purification, biochemical and cellular assays Reconstitution of multi-protein and protein:RNA complexes Assay development Cryo-electron Microscopy SAXS FRET; FRET-FLIM Super-resolution microscopy The control