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combining high-plex imaging, spatial data analysis, and machine learning. One arm of the project will seek to engineer diverse quantitative features (e.g., adapting concepts and metrics from network science
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to understand the fundamental mechanisms of inflammation triggered by permeabilized mitochondria. It will entail a variety of cutting-edge methods including genome-engineering, high-resolution microscopy and in
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, and access to beyond-state-of-the-art technology. To gain quantitative molecular knowledge on the formation of Staufen1:RNA complexes, this project will focus on the detailed individual analysis
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