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the HUSH epigenetic transcriptional silencing complex, which silences newly integrated retroelements (retroviruses/retrotransposons). We recently showed how HUSH distinguishes 'self' from 'non-self' genomic
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We are looking for a bright and motivated Research Assistant to join our team at the CRUK Cambridge Institute (part of the University of Cambridge) to develop new technologies for the study of gene
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) at the University of Cambridge Early Cancer Institute (https://www.earlycancer.cam.ac.uk ). We are focussed on developing accurate and scalable tests that could make a significant contribution to reducing the number
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can lead statistical genetics analyses for rare diseases, including epigenetics. The postholder ideally will already have experience in statistical genetics, rare or complex disorder genetics and show a
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) at the University of Cambridge Early Cancer Institute (https://www.earlycancer.cam.ac.uk ). We are focussed on developing accurate and scalable tests that could make a significant contribution to reducing the number
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of mouse embryonic stem cells, focusing on uncovering epigenetic and co-factor-dependent mechanisms underlying these processes, including exploring data already collected. There is also an opportunity
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of these cells including proteomic, transcriptomic and epigenetic approaches. We utilise cells isolated from primary human tissue samples and organoid systems. As part of our team, you will contribute to ground
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Cambridge Biomedical Campus as well as in the NIHR Cambridge Clinical Research Facility https://www.cambridgecrf.nihr.ac.uk/ based in Cambridge University Hospitals NHS Foundation Trust. Applicants will be
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studies the mechanisms of epigenetic regulation of developmental processes and genome function in mammals. The current focus of the research group is the role of genomic imprinting in the regulation
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Cancer Research UK and is a collaboration between Professor Sir Shankar Balasubramanian at Cancer Research UK's Cambridge Institute (CI) and Professor Rebecca Fitzgerald in the University of Cambridge's