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Developmental & Stem Cell Biology, are developing a common theoretical framework for addressing these questions. Beyond the system-specific molecular and cellular mechanisms, we aim to identify dynamical
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an optimal handling of antigens by DCs optimizing T and B cell responses and increasing anti-infectious protection. This project will be developed in the context of an influenza vaccine already developed in
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Post-Doctoral Researcher Position at the Institut Pasteur in Paris Open position at the Biology of Spirochetes Unit, https://research.pasteur.fr/en/team/biology-of-spirochetes/ in the department
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Multi-omic Analysis and Methodological Development for the Evolutionary Study of the Uterine Mucosa in Mammals The EVUTERO project (Functional Evolution of the Uterine Mucosa in Mammals) aims
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to generate tissue compartmentalization, aiming at recapitulating a T cell zone dedicated to DC / T cell interactions and a B cell zone where germinal center-like structures may develop. In first intent, T cell
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://research.pasteur.fr/fr/department/immunology/ ). The Guermonprez lab investigates the role of dendritic cell subsets in regulating T cell responses and explores novel immunotherapeutic approaches (https
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the interface of machine learning and biology, developing innovative machine learning methods for single-cell data analysis (tools developed by the team: https://github.com/cantinilab). Single-cell high
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perturbations), pharmacological interventions (senolytics and senomorphics), and organoid systems with functional assays, flow cytometry, advanced imaging, and high-dimensional approaches, including single-cell