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Project Outline: Novel Subjective Measure: We recently developed an internationally validated tool to measure a subclinical, reversible stage of pre-chronic health that we coined the 'Suboptimal Health Status' (SHS), which is a physical state between health and disease characterised by 1) the...
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Project Outline: Over recent years, research has shifted towards studying the impact of modifiable lifestyle factors such as dietary interventions and physical activity on Alzheimer’s Disease risk reduction. In particular, three dietary patterns have been studied with respect to cognitive...
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Project Outline: Alzheimer’s disease (AD), the most prevalent form of dementia, ranks among the leading chronic disorders with increasing global public health importance. Evidence from conventional observational studies indicates that AD often co-occurs with several conditions more than expected...
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Project Outline: Background: Informal carers are a significantly disadvantaged group within the population. Carers are at increased risk of poor health, with the role associated with a higher mortality rate than non-caring counterparts. Caring can lead to multiple psychological changes, such as...
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Project Outline: A global rise in life expectancy comes with an increased burden of serious life-long health issues and the need for useful real-time indicators of the ageing process. We propose to investigate the value of biochemical profiles of lgG N-glycosylation in blood as clinically...
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Project Outline: The glycome is the entire complement of sugars, whether free or present in more complex molecules, of an organism. An alternative definition is the entirety of carbohydrates in a cell. The glycome may in fact be one of the most complex entities in nature. Glycosylation, the...
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Project Outline: Neurofilament light chain protein (NFL) levels in plasma and CSF have been reported to be increased in Alzheimer’s disease (AD) and other neurological diseases, making it a generic marker for neurodegeneration. AD is a highly complex and heterogenous disorder and thus a single...
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Project Outline: Proper function of the nervous system is vital to allow muscles to contract. Indeed, exercise training results in improved muscle performance. Conversely, with de-training or ageing the loss of strength can result in poor health and physical function. However, the specific...
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Project Outline: The project will be situated within a program of research on the prevention of hospital acquired complications and will align with the Australian National Safety and Quality Health Service (NSQHS) Standards and Western Australian Sustainable Health Review that aim to protect the...
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Project Outline: Cancer survivors are living longer with improving detection and treatment techniques, so it is becoming increasingly important to develop strategies to improve their health into survivorship. Common cancer therapies have a range of adverse effects, which may include an increased...