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with multiple electrodes – multipolar catheters – are increasingly used to facilitate electroanatomic mapping of the atria before ablation. Despite advances in ablation technology, the search for optimal
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. This thesis aims to model, optimize, and experimentally validate such an optical ultrasound sensor based on resonant metasurfaces. The work will focus on three main areas: 1. Multi-physics Modeling: Development
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(ISCR), is to design electrochemical and optical tools to analyze this process, enabling determination of optimal conditions for surface functionalization. This will require the development of two new
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of the tissue using water-soluble clearing and refractive index matching media, and evaluating the benefits of this approach for three-dimensional imaging. The first year of the project will focus on optimizing
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cellular changes. Advanced imaging techniques, including structural and functional-MRI, developed by Dr. Emmanuel Barbier (GIN director), will be used to optimize rSynES and monitor neuronal changes over
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perfusion and mechanical stimulation in tumor tissues to investigate their poromechanical properties and optimize molecular transport within explants. The successful candidate will be involved in: - Designing
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fluorescence microscope optimized for imaging individual cells within microtumors. Through this work, the PhD candidate will receive hands-on training in the design, implementation, and optimization of a state
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crack initiation and propagation; Development and validation of a digital twin with an appropriate level of maturity; Proposal and evaluation of new cluster architectures; Validation of optimized
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capable of predicting optimal PISA formulations and significantly reducing experimental screening efforts. The successful candidate will receive multidisciplinary training spanning polymer chemistry
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desorption methods; Applying and optimizing a minimally intrusive vapor-phase isotopic exchange method (²H/¹H and/or ³H/¹H) to quantify the accessibility of reactive sites within insoluble organic matter