13 experiment-"https:"-"https:"-"https:"-"https:"-"https:"-"https:"-"https:"-"https:" positions at Amsterdam UMC
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experience in AI-generated GPRC5B-targeting nanobodies and the functional characterisation of nanobodies in relation to GPRC5B signalling. Planned secondments will provide hands-on experience in the generation
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unique expertise in human neuropathology. The team has extensive experience with human tissue, histology, cell culture, microscopy and advanced molecular techniques, including transcriptomic analyses
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type I collagen, a key structural protein in bone. These mutations lead to abnormal collagen quantity or quality, resulting in thin, porous and poorly organised bone. People with OI can experience
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capture the experiences of people with these rare diseases, particularly those who are severely affected or unable to communicate verbally. This project aims to address this gap and improve our
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will also undertake secondments. These will provide hands-on experience in regulatory science and orphan-drug analysis at Amsterdam UMC platform Medicijn voor de Maatschappij, as well as experience with
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potential in vivo. The project requires a strong foundation in neuroscience and an interest in both stem cell-based and animal research. Prior experience with cell culture techniques, behavioural and
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, including bridgeRNA-guided recombinases, to investigate therapeutic efficacy. The project requires relevant experience in molecular techniques and an interest in responsible and scientifically robust use
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therapies. Planned secondments will provide experience in omics data generation and biomarker development in an industrial and regulatory setting, including a placement at Orchard Therapeutics. A secondment
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include: planning, preparing and performing molecular and cellular laboratory experiments; working with patient-derived organoids, xenograft tumour models and gene delivery, expression and gene silencing
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secondments will provide hands-on experience in in vitro assay validation and in vivo characterisation of lead molecules. You will use molecular receptor pharmacology techniques to investigate the orphan GPCR