15 applied-physic-"https:"-"https:"-"https:"-"https:"-"https:" positions at Amsterdam UMC
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of artificial intelligence, cardiovascular engineering, and clinical medicine, with the potential to contribute directly to the future of personalized cardiovascular care. As a PhD candidate, you will work
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for human CAA. You will investigate whether the blood-brain barrier is disrupted in this model and whether interventions targeting the blood-brain barrier influence the course of CAA. You will use a
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not sufficiently restore bone quality or fracture healing, and there is currently no curative therapy. Within this project, you will use the broken-bone-on-chip (BBoC) model to study how human OI bone
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used to model leukodystrophies because of their genetic tractability and the ability to study early brain development. To strengthen their use as preclinical models, this project will develop outcome
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department is highly interdisciplinary with informatics researchers working closely together with practicing cardiologists to advance the use of AI for personalised treatment. The ultimate goal is to be able
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investigated as drug targets. The aim of the project is to understand how the orphan receptor is activated and signals, develop high-throughput screening assays and identify drug-like modulators. You will use
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disease (VWM) and metachromatic leukodystrophy (MLD). You will investigate the efficacy and safety of AAV gene therapy in VWM and MLD mouse models. In addition, you will use genome-editing approaches
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institutions and several industrial partners with extensive expertise in quantitative imaging, image analysis and imaging technology. By conducting research in both academic and industrial settings, PhD
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consortium. Your academic supervision will be provided by Prof. Timo De Groof and Prof. Nick Devoogdt. This doctoral project focuses on developing GPRC5B-targeting nanobodies for use as research tools
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. You will use human in vitro models, including astrocytes and brain organoids generated from induced pluripotent stem cells (iPSCs) of people with MLC and healthy controls. You will investigate disease