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-based perturbations, base/prime editing, and targeted epigenetic modulation). Functional genomics in neuronal systems, including transcriptomic and epigenomic profiling. Model systems such as human iPSC
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the same genetic material generate markedly different cells, and how this information is encoded within the genome. We utilize stem cells and cancer model systems, though projects range across disciplines
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application of unique mouse models for in vivo pathway discovery and validation. Experience or interest in flow cytometric analyses, and basic immunological techniques will be essential and interest in
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stress affects specific cell types in the nervous system and the gut, using human pluripotent stem cell (hPSC)-derived models of the enteric nervous system. Our work sits at the intersection of stem cell
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-tracing mouse models, lung injury and tumor-initiation systems, single-nucleus multiome (RNA and ATAC) and spatial profiling, and validation in human early-stage lung adenocarcinoma specimens. The position
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established internationally recognized experimental platforms for the study of intraerythrocytic parasites, parasite metabolism, chemical biology, and preclinical models for therapeutic discovery and
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of research, scientific communication, and the translation of computational models into clinically meaningful tools. Individual development goals will be established at the beginning of the appointment and
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. Building on this platform, we combine cell biology, biochemistry, CRISPR-based approaches, organelle isolation, metabolomics and proteomics, mouse genetics, and disease models to discover principles of ER
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program. Our work focuses on the development of advanced cancer models, integrative genomic analyses, and the discovery of novel therapeutic strategies. Using systematic, interdisciplinary approaches
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that include mid-circuit measurements and feedforward Quantum simulation of many-body and lattice-gauge theory models Microscopic physics of Josephson junctions Other topics of mutual interest About the Yale