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infected human cells, identify viral and host complexes in their native context, and combine this with structural modeling and proteomics to build a spatially and temporally resolved picture of the infection
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analyze data, with minimum supervision, to test specific hypotheses. Expert ability to distill, convey and present complex information in a clear and concise manner both verbally and in writing is essential
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. amino acid and lipid metabolism), signaling pathways (e.g. mTOR and nutrient signaling), and systems-level regulatory networks that regulate basic T cell and dendritic cell biology and antitumor immunity
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CYP3A5-selective inhibitor and its structural basis (J Am Chem Soc 143:18467, 2021). Our goal is to understand nuclear receptor-regulated transcription networks, enzyme-drug interactions, and design
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protein complexes exist in their native cellular environments a central challenge in understanding the molecular logic of these pathogenic bacteria. By combining cutting-edge proteomics and structural
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are often tied to their subcellular localization and the biological processes they are involved in. We have extensively characterized how the molecular grammar of prion-like low-complexity domains encode
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, computational models, and systems biology to elucidate the mechanisms of drug interactions in complex biological systems, with a particular focus on infectious disease. Ideal candidates will have: • A Ph.D. in
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driving a complex research project. Scientific writing skills, including experience contributing to or drafting manuscripts. Experience with CRISPR-based perturbation approaches, drug-response assays, high
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required. Ability to rapidly learn, optimize, and implement new or advanced techniques as required by the evolving research direction. Experience leading or substantially driving a complex research project
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investigators. Biostatistics methods will include complex survival analysis, longitudinal analysis, machine learning, and causal inference. You will benefit from access to unique datasets and expertise from two